Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 Buono Peptide Anti-age Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 at a glance Derived from a plant native to Australia Claimed to stimulate collagen production Supplier data compares benefits to retinoids More independent research needed Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 description _Nicotiana benthamiana_ hexapeptide-40 sh-polypeptide-76 is one of several signal peptides derived from the Nicotinana benthamiana plant, which is native to Australia and is related to the tobacco plant. _Nicotiana benthamiana_ hexapeptide-40 sh-polypeptide-76 is claimed by its manufacturer to stimulate collagen production, specifically type 1 collagen, the most abundant form of collagen in skin. Not surprisingly, collagen 1 is most associated with preserving skin’s elasticity and firmness. _Nicotiana benthamiana_ hexapeptide-40 sh-polypeptide-76 is also known by the trade name Reneseed™. More independent study is needed to confirm its manufacturer’s claims, though peptides in general help skin behave in a healthier manner. The supplier has comparative clinical data showing this plant-derived peptide is an alternative to retinoids. The recommended use level of this peptide (as Reneseed) is 1.5–2% when supplied in a water-soluble solution. Related ingredients: Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1