Hexapeptide-48 HCL Buono Peptide Anti-age Idratare Hexapeptide-48 HCL at a glance Claimed to target intrinsic + extrinsic aging Works with skin’s opioid receptors Can influence the health-promoting delta opioid receptor Known by the trade name Rubixyl® Hexapeptide-48 HCL description Hexapeptide-48 HCl is a synthetic peptide that’s also known by the trade name Rubixyl® where it’s combined with water and glycerin. The manufacturer of this peptide claims it can target visible signs of aging caused by both intrinsic (internal, caused by time) and extrinsic (external, environmentally caused) factors. Emerging independent research demonstrates this may indeed be the case. Studies show that hexapeptide-48 HCL can interact with and influence opioid receptors within skin, particularly the delta opioid receptor. Recent studies into the expression of this receptor show that it can have an influence on skin barrier function, hyperpigmentation and multiple signs of aging including fine lines and deeper wrinkles. Some studies demonstrate that hexapeptide-48 HCL can have a moderating effect on the delta opioid receptor, influencing it to act in a healthy, “normal” manner, thereby stopping (or at least slowing) some of the root causes of skin aging. There isn’t a broad amount of data yet on this intriguing relationship, but research so far is encouraging. It’s definitely an ingredient we will be watching! The recommended use level of hexapeptide-48 HCI is 1% when supplied in a water-based blend. Related ingredients: Peptides